Abstract #2005

Off-resonance effects on infant pCASL

Zhenyu Zhang¹, Yushuang Ding², Ruoge Lin¹, Weiying Dai³, David Alsop⁴, Hongxi Zhang², and Li Zhao¹

¹College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, ²Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China, ³Department of Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ⁴Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, infant; labeling efficiency; off-resonance

Motivation: The image quality of ASL in infants is variable.

Goal(s): To investigate the labeling efficiency in infant pCASL.

Approach: Labeling efficiency was simulated using the Bloch equation. Prospective scans were performed on 11 subjects, with pCASL at 60mm and 90mm below the AC-PC line, MRA, and B0 map.

Results: Blood flow velocity has negligible effects on the labeling efficiency at the on-resonance frequency. The combined effects of off-resonance and the high blood flow velocity are the primary cause of the variable image quality. pCASL images at 60mm showed improved SNR in 8 /11 infants, compared to that of 90mm.

Impact: This study examined the factors contributing to variable ASL images in infant and provided a preliminary solution by selecting the labeling plane.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.