Keywords: Arterial Spin Labelling, Arterial spin labelling
Motivation: Current Fourier Transform-based velocity-selective inversion (VSI) pulses are sensitive to field inhomogeneities, leading to labeling errors or inefficiency.
Goal(s): To improve the labeling robustness and efficiency of the VSI pulses for more robust and high-SNR perfusion measurement.
Approach: A new design with 6-segment FT-VSI pulse was implemented and tested in healthy subjects using dual-module VSI labeling.
Results: Compared with the existing VSI pulse, the new pulse significantly improved the labeling robustness against field inhomogeneities and the overall labeling efficiency, leading to >15% higher ASL signal (p<0.0002) and >20% higher temporal SNR (p<0.009).
Impact: This new VSI pulse can effectively improve the labeling robustness against field inhomogeneities, while increasing the labeling efficiency and reducing the SAR. These features are especially beneficial with dm-VSASL implementation and in ultra-high field applications for delay-insensitive ASL perfusion imaging.
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