Meeting Banner
Abstract #2034

Direct myelin imaging using a 3D double adiabatic inversion recovery prepared ultrashort echo time (3D DIR-UTE) cones sequence

Jiyo S Athertya1, James Lo1,2, Qingbo Tang3, Kenichiro Doi1, Soo Hyun Shin1, Dina Moazamian1, Melissa Lou1, Arya Suprana1,2, Bhavsimran Singh Malhi1, Eric Y Chang1,3, Jiang Du1,2,3, and Yajun Ma1
1UCSD, San Diego, CA, United States, 2Dept of Bioengineering, UCSD, San Diego, CA, United States, 3Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, United States

Synopsis

Keywords: White Matter, White Matter, UTE imaging, Myelin

Motivation: Many neurological disorders are characterized by myelin damage and loss. Robust long T2 suppression is of critical importance for accurate myelin quantification due to myelin's low proton densities.

Goal(s): To develop a new UTE imaging approach that enables sufficient long T2 suppression for selective myelin imaging.

Approach: A 3D DIR-UTE sequence was developed for selective myelin imaging on a 3T clinical scanner. The technical feasibility was tested by phantom and in vivo studies.

Results: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%.

Impact: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords

myelinlong