Keywords: White Matter, White Matter, UTE imaging, Myelin
Motivation: Many neurological disorders are characterized by myelin damage and loss. Robust long T2 suppression is of critical importance for accurate myelin quantification due to myelin's low proton densities.
Goal(s): To develop a new UTE imaging approach that enables sufficient long T2 suppression for selective myelin imaging.
Approach: A 3D DIR-UTE sequence was developed for selective myelin imaging on a 3T clinical scanner. The technical feasibility was tested by phantom and in vivo studies.
Results: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%.
Impact: The long T2 signals were sufficiently suppressed with the DIR scheme. The myelin proton fraction in white matter regions quantified by the DIR-UTE was 5.42±0.35%.
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