Keywords: Structural Connectivity, Brain Connectivity, Functional connectivity
Motivation: EEG measured directional information flow, cerebral metabolism and structural connectivity are altered in temporal lobe epilepsy, although their interplay have not been elucidated.
Goal(s): To investigate whether and how structural and metabolic connectivity may separately or jointly affect the directional information flow.
Approach: This study proposed a step-wise analysis to study the correlation between directional information flow measured by SEEG and glucose metabolism measured by FDG PET, and to explore their associations with different structural connectivity.
Results: The inward information flow was negatively correlated with FDG uptake. White matter structural connectivity modulated the relationship between SEEG information flow and metabolism.
Impact: Unraveling the underlying association of white matter connectivity and FDG metabolism with directional information flow strength could offer a comprehensive view of neuronal signal propagation and potentially improve seizure onset localization of focal epilepsy.
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