Keywords: Structural Connectivity, Diffusion Tensor Imaging, Major depressive disorder; Structural connectome; Graph theory
Motivation: Previous studies have demonstrated brain abnormalities in adolescents with major depressive disorder (MDD); however, how the topological organization of brain networks is affected is still unclear.
Goal(s): This study aimed to investigate the white matter (WM) structural topology in adolescent MDD.
Approach: The topological metrics of WM structural brain networks were analyzed using graph theory method.
Results: Adolescent MDD patients showed disrupted topological organization at the global, rich-club and modular levels, exhibited abnormal nodal centralities in multiple regions, and had a decrease in the coupling between structural and functional connectivity.
Impact: Our findings suggest widespread disruption of structural brain networks and structural-functional decoupling in adolescent MDD, which may provide new insights into the neurobiology of adolescent MDD.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords