Abstract #2050

Comparison of white matter bundle structure between humans and macaques.

Kazuya Ouchi^1,2, Daisuke Yoshimaru^1,3, Aya Takemura², Noriyuki Higo², Shinya Yamamoto^2,4, Ryusuke Hayashi², Yasuko Sugase-Miyamoto², and Tomokazu Tsurugizawa^1,2,3

¹Faculty of Engineering, Information and Systems, University of Tsukuba, Ibaraki, Japan, ²National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan, ³Jikei University School of Medicine, Tokyo, Japan, ⁴Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan

Synopsis

Keywords: Structural Connectivity, White Matter

Motivation: Comparative studies on brain structure between humans and macaques across entire brain have not been thoroughly conducted.

Goal(s): The goal of this study is to show the similarities and differences of structural connectivity (SC) in humans and macaques.

Approach: SC was calculated from diffusion-weighted imaging. Based on the SC, the similarity and Least Absolute Shrinkage and Selection Operator (LASSO) were used.

Results: High similarity of SC between and within species was observed. LASSO yielded feature extraction of 12 connections.

Impact: This study clearly showed the similarity of white matter structure between and within species in humans and macaques. The method of this study is quantitative and provides valuable insights in translational research.

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