Keywords: Functional/Dynamic, Spectroscopy
Motivation: Bridge the knowledge gap in understanding the central mechanisms of chronic low back pain (CLBP) and the effects of spinal manipulation (SM).
Goal(s): To use 1H-MRS to investigate metabolic differences in the posterior cingulate cortex (PCC) during spinal manipulation for chronic low back pain (CLBP).
Approach: The approach involved recruiting CLBP patients and healthy controls, performing 1H-MRS in the posterior cingulate cortex (PCC) before and after spinal manipulation (SM), and correlating metabolite changes with clinical outcomes.
Results: CLBP patients exhibited altered brain metabolism in the posterior cingulate cortex (PCC), with changes in specific metabolites, and these abnormalities improved after spinal manipulation (SM).
Impact: The research provides insights into the central mechanisms of chronic low back pain (CLBP) and the potential therapeutic benefits of spinal manipulation, which could inform better pain management strategies.
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