(ISMRM 2024) The changes of brain metabolism after spinal manipulation in patients with chronic nonspecific low back pain: a MRS study
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Abstract #2060

The changes of brain metabolism after spinal manipulation in patients with chronic nonspecific low back pain: a MRS study

Wenli Tan1, Hui Chen1, Miao Huo1, and Mengxiao Liu2
1Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China, 2MR research Collaboration, Siemens Healthineers Ltd, Shanghai, China

Synopsis

Keywords: Functional/Dynamic, Spectroscopy

Motivation: Bridge the knowledge gap in understanding the central mechanisms of chronic low back pain (CLBP) and the effects of spinal manipulation (SM).

Goal(s): To use 1H-MRS to investigate metabolic differences in the posterior cingulate cortex (PCC) during spinal manipulation for chronic low back pain (CLBP).

Approach: The approach involved recruiting CLBP patients and healthy controls, performing 1H-MRS in the posterior cingulate cortex (PCC) before and after spinal manipulation (SM), and correlating metabolite changes with clinical outcomes.

Results: CLBP patients exhibited altered brain metabolism in the posterior cingulate cortex (PCC), with changes in specific metabolites, and these abnormalities improved after spinal manipulation (SM).

Impact: The research provides insights into the central mechanisms of chronic low back pain (CLBP) and the potential therapeutic benefits of spinal manipulation, which could inform better pain management strategies.

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Keywords

painpatientsmanipulationspinalsixth