Abstract #2064

Iron Deposition Characteristics in Normal-appearing White Matter: A Community Study Using Quantitative Susceptibility Mapping Method

Yian Gao¹, Meng Li², Qihao Zhang³, Jing Li⁴, Mengmeng Feng⁵, Haotian Xin⁵, Chaofan Sui¹, Changhu Liang¹, and Lingfei Guo¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Jena University Hospital, Jena, Germany, ³Department of Radiology, Weill Medical College of Cornell University, New York, NY, United States, ⁴Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, China, ⁵Department of Radiology and Nuclear medicine, Capital Medical University, Beijing, China

Synopsis

Keywords: White Matter, Neurodegeneration

Motivation: The factors that influence iron deposition in the normal-appearing white matter (NAWM) of the brain have yet to be thoroughly examined.

Goal(s): This study aimed to measure brain iron levels in a community population and identify factors affecting NAWM iron levels.

Approach: Brain iron load was assessed using quantitative susceptibility mapping.

Results: Age, hypertension, T2DM, smoking, BMI, and APOE4 affect iron metabolism in certain NAWM brain regions. Moreover, the mean susceptibility values of the corpus callosum are significantly related to some cognitive tests.

Impact: We could identify the potential factors that could affect iron levels in the white matter and accurately map iron in this part of the brain. This information could help us better control confounding variables in future research.

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