Abstract #2066

Abnormal white matter integrity revealed by Tracts Constrained by Underlying Anatomy (TRACULA) in obsessive-compulsive disorder

Shuangwei Chai¹, Hailong Li¹, Jiaxin Jiang², Lingxiao Cao¹, Huan Zhou¹, Bin Li², and Xiaoqi Huang¹

¹Department of Radiology and Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China, ²Mental Health Center, West China Hospital of Sichuan University, Sichuan Clinical Medical Research Center for Mental Disorders, Chengdu, China

Synopsis

Keywords: White Matter, White Matter, obsessive-compulsive disorder

Motivation: Diffusion tensor imaging (DTI) is a useful imaging technique to investigate white matter (WM) integrity and previous studies had revealed the disruption of WM related to neuropathology in obsessive-compulsive disorder (OCD). However, few study had reliably located the defect at track level.

Goal(s): To investigate the WM integrity in OCD on a whole brain level using newly developed tractography method.

Approach: We used Tracts Constrained by Underlying Anatomy (TRACULA) software to investigate the WM integrity in OCD.

Results: We found widespread disruption of WM integrity in OCD, and for the first time, we observed abnormality in bilateral acoustic radiation in OCD.

Impact: Using the innovated fiber tractography methodology, we were able to detect abnormality in bilateral acoustic radiation in OCD, which had been suggested by previous study using resting state fMRI.

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