Keywords: White Matter, White Matter
Motivation: White matter lesion (WML) is a neuroimaging signature of cerebral small vessel disease (CSVD), commonly comprising both vascular and nonvascular components for which assessment methods remain to be developed.
Goal(s): To investigate the feasibility of using multimodal MR imaging to separate vascular and nonvascular components in WML.
Approach: Twelve patients with CSVD were prospectively included and underwent 3T MR imaging. Magnetization transfer ratio (MTR) was derived from magnetization transfer imaging. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were derived from diffusion tensor imaging.
Results: MTR was found to correlate with ADC and FA differently in WML as compared to normal-appearing white matter.
Impact: Appropriate separation of vascular/nonvascular components in WML can help differential diagnosis and treatment formation of CSVD. The sensitivity of combined MTR/FA/ADC can be further verified by comparing CSVD with other neurological diseases that present WML but have nonvascular pathogenesis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords