Keywords: White Matter, Aging, cognitive impairment
Motivation: It is still unclear what the mechanism of the effect of white matter hyperintensities (WMHs) and cognitive impairment is.
Goal(s): To use intravoxel incoherent motion (IVIM) to evaluate the microvascular and parenchymal microstructural changes of WMHs and to investigate their association with cognitive impairment.
Approach: The IVIM parameters were compared between patients and controls, different ROIs, and different WMH severity. Additionally, a multivariate linear regression analysis was conducted to explore the factors influencing cognitive scores.
Results: WMH patients had higher parenchymal diffusivity than the control group. Furthermore, increased parenchymal diffusivity was associated with an increased risk of cognitive decline.
Impact: The IVIM technique has the potential to provide a quantitative marker of parenchymal diffusivity for assessing the severity of WMH and may be useful in quantifying cognitive dysfunction in patients with WMH.
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