Keywords: Infectious Disease, Metabolism
Motivation: Many long-COVID patients experience fatigue and post exertional malaise which are primary symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Understanding the similarities and differences between long-COVID and classic ME/CFS could provide insights into the disease mechanisms.
Goal(s): To measure brain anatomy and oxygen metabolism between the two groups.
Approach: Clinical standard and advanced MRI techniques measuring the venous oxygenation were applied. The fatigue level was assessed by questionnaires.
Results: No differences in brain anatomy were observed between the groups, but the long-COVID group had significant lower venous oxygenation than the healthy control group and the classic CFS group.
Impact: Many long-COVID patients fulfill diagnostic criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Compared to structural changes, metabolism-related parameters, such as venous oxygenation of the brain, may be more sensitive to changes related to long-COVID and CFS disease mechanisms.
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