Keywords: Infectious Disease, COVID-19, Magnetic Resonance Spectroscopy, Anosmia, Orbitofrontal Cortex
Motivation: Olfactory impairments caused by COVID-19 have been addressed in neuroimaging findings over the past years. However, long-term complications on brain orbitofrontal cortex (OFC) needs to be further investigated.
Goal(s): Our goal was to assess metabolites level change in the brain OFC region in COVID-induced anosmia subjects in comparison to healthy population.
Approach: 54 subjects categorized into control, short- and long-term anosmia groups were studied using single voxel MRS. Metabolite level alterations of their brain OFC region were investigated.
Results: We found that NAA, Cho, and Cr levels in brain OFC region decreased as COVID-induced anosmia duration and severity increased.
Impact: The demonstrated results of alteration in brain metabolites level influenced by the severity of COVID-induced anosmia highlights MRS as a robust assessment tool for physicians to better investigate olfactory function impairment in the brain orbitofrontal cortex.
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