Abstract #2076

Dysfunction of glymphatic system in recovered COVID-19 patients: A diffusion tensor image analysis along the perivascular space (DTI-ALPS)

Lin Wu^1,2,3, Zhi Zhang^1,2,3, Jiankun Dai⁴, Meng Li^5,6, and Fuqing Zhou^1,2,3

¹Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China, ²Jiangxi Province Medical Imaging Research Institute, Nanchang, Jiangxi, China, ³Clinical Research Center For Medical Imaging, Nanchang, Jiangxi, China, ⁴MR Research, GE Healthcare, Beijing, China, ⁵Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Jena, Germany, ⁶Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany., Jena-Magdeburg-Halle, Germany

Synopsis

Keywords: Infectious Disease, COVID-19, Glymphatic system;DTI-ALPS

Motivation: Central nervous related sequelae are often reported in recovered COVID-19 patients. It’s unclear whether recovered patients have glymphatic impairment and clinical correlation.

Goal(s): Assessing glymphatic function in recovered patients and the clinical correlation.

Approach: 61 recovered patients and 38 healthy controls were enrolled. Glymphatic function was assessed using DTI-ALPS and compared between recovered and HC subjects.

Results: The impairment of glymphatic function was observed in recovered patients and was more obvious in older patients. It was correlated with sleep quality and anxiety status in a subgroup of recovered patients.

Impact: Our study firstly provided evidence of glymphatic function impairment in recovered COVID-19 patients.

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