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Abstract #2075

White matter alterations in brain fog: A Long-Covid study

Nicolò Rolandi1,2,3, Antonio Ricciardi2, Elena Grosso3, Madiha Shatila2, Marios C. Yiannakas2, Ferran Prados2,4,5, Baris Kanber2,4, Jed Wingrove2, Francesco Grussu2,6, Marco Battiston2, Rebecca S. Samson2, Carmen Tur7, Fulvia Palesi3,8, Egidio D'Angelo3,8, and Claudia A. M. Gandini Wheeler-Kingshott2,3,8
1Department of Clinical and Experimental Epilepsy, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 3Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 4Department of Medical Physics and Biomedical Engineering, Centre for Medical Image Computing (CMIC), University College London, London, United Kingdom, 5E-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain, 6Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 7Neurology-Neuroimmunology Department Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 8Digital Neuroscience Center, IRCCS Mondino Foundation, Pavia, Italy

Synopsis

Keywords: Neuroinflammation, COVID-19

Motivation: The symptoms of brain fog include problems with concentration, memory, attention, which result in difficulties with communication. This can make it extremely difficult for an individual to carry out daily tasks and responsibilities as well as maintain relationships deteriorating their quality of life.

Goal(s): To investigate white matter alteration in Long-COVID.

Approach: Voxel-wise analysis of core white matter voxels using advanced MRI metrics and neuropsychological scores.

Results: Results highlight promising perspective for further investigations and potential clinical interpretation of Long-COVID syndromes

Impact: The addition of MRI enables a more thorough exploration of the diverse cognitive dimensions affected in individuals experiencing brain fog and perhaps the possibility to understanding the involvement of WM alterations as either a risk factor or consequence of Long-COVID.

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Abstract

Keywords