Keywords: Infectious Disease, COVID-19
Motivation: Brain network alterations in acute phase of coronavirus disease 2019 patients (acute-COVID) with fatigue has not yet been elucidated.
Goal(s): Our goal was to determine the characteristics of alterations in brain network and the neurobiological mechanisms in acute-COVID patients with fatigue.
Approach: We utilized graph theory analysis to assess brain network alterations in COVID-19 patients.
Results: Results demonstrated the abnormalities in brain network in acute-COVID patients with fatigue, involing left insular gyrus and right inferior frontal gyrus. Morever, the normalized characteristic path length of global brain in acute phase of COVID-19 could predict the development of chronic symptoms.
Impact: Our functional MRI findings highlight abnormal brain network metrics in acute phase COVID-19 patients with fatigue, offering valuable neuroimaging marker for early clinical intervention in long-COVID patients.
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