Abstract #2085

Insights into Neurological Long COVID Syndrome with Quantitative Susceptibility Mapping in Basal Ganglia

Jia Ying^1,2, Chuan Huang^1,2,3, Zennur Sekendiz⁴, Ashley Fontana ⁴, Sean Clouston⁵, Minos Kritikos⁵, and Benjamin Luft⁶

¹Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ³Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, United States, ⁴Medicine, Stony Brook University, Stony Brook, NY, United States, ⁵Family, Population, and Preventive Medicine, Stony Brook University, Stony Brook, NY, United States, ⁶World Trade Center Health and Wellness Program, Stony Brook University, Stony Brook, NY, United States

Synopsis

Keywords: Infectious Disease, Quantitative Susceptibility mapping, PASC, COVID-19

Motivation: The etiology of persistent and enigmatic neurological symptoms in post-acute sequelae of COVID-19 (PASC) remains unclear.

Goal(s): To utilize quantitative susceptibility mapping (QSM) to compare iron levels in the basal ganglia of individuals with neurological symptoms of PASC, recovered COVID-19 patients, and uninfected controls, thereby identifying potential biomarkers for the condition.

Approach: QSM imaging was performed on three distinct cohorts: PASC, post-COVID non-PASC, and uninfected subjects

Results: Elevated QSM values, indicative of iron accumulation, in the putamen and caudate nucleus were observed in PASC patients.

Impact: The study aims to offer a novel imaging perspective on PASC, potentially leading to a better understanding of its neurological aspects and aiding in the development of targeted therapies for affected patients.

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