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Abstract #2084

Neurochemistry, microstructure, and perfusion in long-COVID: An interim analysis from a multisite study

Ana I Silva1, James M Joers1, Katherine Gundry1, Alfredo Lorente1, Jeromy Thotland1, Dinesh K Deelchand1, Young W Park1, Xiufeng Li1, Georgios E Manousakis2, Abby I Metzler2, Christophe Lenglet1, Lynn Eberly1,3, June C Kendall4, Michel Toledano4, Orhun H Kantarci4, Merve Atik4, Matthew L Senjem4, Burcu Zeydan4, Keenan C Byrne5, Meher R Juttukonda5,6, David H Salat5, Janet C Sherman5, Lauren Pollak5, Shibani Mukerji5, G Kyle Harrold5, Sevil Yasar7, Mehreen Nabi7, Sana Rehman7, Christof Karmonik8, Syed A Gillani8, Valerie Flores8, Rachel Davis8, Tetsuo Ashizawa8, Peter B Barker7, Eva M Ratai5, Kejal Kantarci4, and Gülin Öz1
1Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, United States, 2Department of Neurology, University of Minnesota, Minneapolis, MN, United States, 3School of Public Health, Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States, 4Mayo Clinic, Rochester, MN, United States, 5Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 6Department of Radiology, Harvard Medical School, Boston, MA, United States, 7Johns Hopkins University, Baltimore, MD, United States, 8The Houston Methodist Research Institute, Houston, TX, United States

Synopsis

Keywords: Infectious Disease, COVID-19, Arterial Spin labelling, Brain, Brain Connectivity, Diffusion Tensor Imaging, Microstructure, Multimodal, Spectroscopy, Perfusion

Motivation: There is an urgent need to understand the biological basis of long-COVID.

Goal(s): To elucidate long-term consequences of SARS-CoV-2 infection in the brain using advanced MRI.

Approach: In a multisite study, we collected single-voxel MRS, diffusion MRI, pCASL and T2 FLAIR MRI, to investigate the neurochemistry, microstructure, perfusion, and white matter hyperintensities (WMH) in participants suffering from long-COVID.

Results: Participants with long-COVID have long-lasting effects (that persist years after acute infection) in the neurochemistry, microstructure, and perfusion, primarily in the brainstem, midbrain and diencephalon, and their connecting tracts, without the presence of overt white matter pathology.

Impact: Multi-modal advanced MRI demonstrates long-lasting effects of COVID-19 in the brain, including neurochemical and microstructural abnormalities and perfusion deficits. These insights may facilitate the treatment and care of people suffering from long-COVID.

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Abstract

Keywords