Keywords: Cancer, Tumor, Nutritional Intervention, MR spectroscopy, Tumor segmentation
Motivation: The evaluation of MR spectroscopy imaging findings with multiparametric brain tumor segmentation might facilitate the understanding of altered tumor metabolism induced by intervention on an individual patient/tumor level.
Goal(s): In this study, we used this approach to elucidate the glioma metabolism under nutritional intervention.
Approach: The concentrations of ketone bodies in brain tumor after 72-hour-fasting were correlated with the volume of glioma sub-regions for 13 brain tumor patients.
Results: The outcome indicates that the accumulation of ketone bodies in solid tumors and necrotic areas after fasting might be a result of neovascularization and the blood-brain barrier compromise.
Impact: Here, we report on the validation of a dedicated, multi-voxel MRSI protocol with fully automated multiparametric segmentation of glioma sub-regions for monitoring fasting-induced changes.
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