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Abstract #2145

Atlas-based analysis of diffusion imaging may predict efficacy of constraint-induced movement therapy in stroke rats

Xinxin Zhao1, Ce Li2, Yulong Bai2, Jianrong Xu1, and Yan Zhou1
1Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, 2Huashan Hospital, School of Medicine, Fudan University, Shanghai, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Data Analysis

Motivation: Atlas-based diffusion imaging of whole brain white matter analysis might be helpful in evaluating obscure motor function recovery in chronic stroke.

Goal(s): Our goal was to evaluate the potential of diffusion imaging atlas-based in predicting motor function recovery in stroke rats with constraint-induced movement therapy.

Approach: We used atlas-based analysis of diffusion imaging to conduct multi-parameter measurements of white matter fibers in the entire brain, combined with catwalk-automated gait analysis to test quantificationally evaluated the motor function.

Results: Atlas-based analysis of diffusion observations indicated that treatment with constraint-induced movement therapy improved microstructural integrity of axon and myelin.

Impact: Atlas-based analysis of diffusion imaging were intended to advance non-invasive imaging approaches for understanding microstructural changes of axon and myelin in chronic stroke.

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Keywords