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Abstract #2148

DTI Denoising by Directional Filtering of k-space Inspired by the Pattern of Gradient Influence

Khashayar Esmaeilzadeh1, Farzaneh Keyvanfard2,3, and Abbas Nasiraei Moghaddam1,2
1Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran (Islamic Republic of), 2School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran (Islamic Republic of), 3Department of Biomedical Engineering, K. N. Toosi University of Technology, Tehran, Iran (Islamic Republic of)

Synopsis

Keywords: Diffusion Analysis & Visualization, Diffusion Tensor Imaging, Diffusion Denoising

Motivation: DTI suffers from intrinsic low SNR compared to conventional MRI, making denoising crucial.

Goal(s): Our study aims to introduce a novel filtration method based on an estimated pattern of areas most directionally affected in the spatial frequency domain.

Approach: A pattern was suggested through DTI theory and observations of simulation data. This was then used to propose a filter for noise reduction. The application of this filter was quantitatively and qualitatively evaluated on simulated MR and DTI images, considering added noise.

Results: The results showed not only the method’s increased robustness to noise but also a clearer representation of white matter tracts.

Impact: By integrating the fundamental concepts of diffusion within the white matter into our filter design, we present a promising approach to denoising DTI data, potentially yielding more reliable and biologically meaningful results, and benefiting researchers investigating brain connectivity.

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