Abstract #2151

Subject-specific analysis approach to longitudinal tracing of heterogeneous white matter abnormalities in sports-related concussion

Ho-Ching Yang¹, Mario Dzemidzic^1,2, Qiuting Wen¹, Larry D Riggen³, Steven P Broglio⁴, Michael A McCrea⁵, Thomas W McAllister⁶, Jaroslaw Harezlak⁷, and Yu-Chien Wu^1,8

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ²Department of Neurology, Indiana University School of Medicine, Indianapolis, IN, United States, ³Department of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Michigan Concussion Center, University of Michigan, Ann Arbor, MI, United States, ⁵Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, WI, United States, ⁶Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States, ⁷Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, United States, ⁸Stark Neurosciences Research Initiative, Indiana University School of Medicine, Indianapolis, IN, United States

Synopsis

Keywords: DWI/DTI/DKI, Diffusion Tensor Imaging, Sport-related concussion, Subject-specific analysis

Motivation: Unlike groupwise approaches, subject-specific analysis has the potential to pinpoint highly individualized abnormalities in white matter structure caused by sport-related concussion (SRC).

Goal(s): Develop a subject-specific analysis approach to investigate the heterogeneity and longitudinal changes in white matter microstructures after SRC.

Approach: The DTI metrics were voxel-by-voxel Z-transformed using a normal distributed template created from non-contact sport controls. The extreme Z maps were obtained, and averaged extreme Z-scores were compared across three study time points.

Results: The existence of heterogeneity in the concussed brains can be appreciated in the projected extreme Z maps and their longitudinal trajectories.

Impact: We developed a subject-specific analysis pipeline to demonstrate heterogeneity in sport-related concussion with respect to anatomical locations and recovery trajectories.

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