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Abstract #2158

ATM: Anatomy to Tract Mapping

Yee-Fan Tan1,2, Siyuan Liu3, Raphaël C.-W. Phan1, Chee-Ming Ting1, and Pew-Thian Yap2
1School of Information Technology, Monash University, Subang Jaya, Malaysia, 2Department of Radiology and Biomedical Research Imaging Center (BRIC), UNC Chapel Hill, Chapel Hill, NC, United States, 3Marine Engineering College, Dalian Maritime University, Dalian, China

Synopsis

Keywords: Tractography, Tractography & Fibre Modelling

Motivation: Conventional diffusion tractography relies on error-prone voxel-to-voxel tracing and typically demands diffusion MRI with high signal-to-noise ratio, spatial and angular resolution, which can be challenging to acquire.

Goal(s): To generate bundle-specific streamlines from anatomical MRI.

Approach: We present a deep learning framework for anatomy to tract mapping (ATM), allowing bundle-specific streamlines to be generated from anatomical MRI. ATM generates streamlines without resorting to voxel-to-voxel tracing, hence sidesteps challenges involved in tracing across complex configurations such as crossings, kissing, and bending and the bottlenecks where multiple bundles converge toward before re-emerging.

Results: ATM effectively captures bundle shapes and generates bundle-specific streamlines from T1-weighted MRI.

Impact: We demonstrate that tract streamlines can be estimated directly from anatomical MRI. This allows (1) tractography in the absence of diffusion MRI and (2) anatomy tractography to guide diffusion tractography.

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