Keywords: Tractography, Tractography & Fibre Modelling
Motivation: Pre-surgical tractography aids neurosurgical planning around key language tracts. Standard reconstruction approaches lead to a trade-off between sensitivity and specificity, and may not characterise all aspects of the target tract.
Goal(s): Increase sensitivity and specificity of reconstruction methods for the inferior fronto-occipital fasciculus and arcuate fasciculus and language tracts.
Approach: A new set of three spherical seed, end, and supplementary waypoint regions of interest (ROIs), defined in MNI space, were implemented using volunteer datasets, and results compared to a reference atlas.
Results: The new 3-ROI approach achieved greater overlap with the reference tracts (higher Dice coefficient), with increased sensitivity and/or specificity.
Impact: Improvements in sensitivity and specificity of reconstructed language tracts using 3-ROI based tractography optimise the characterisation of tracts in healthy volunteers. Further evaluation should now be done to allow extension to clinical cases.
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