Abstract #2172

Analytical T1, T2, proton density, and magnetic field inhomogeneity quantification in the brain using phase-cycled bSSFP

Nils Marc Joel Plähn^1,2,3, Yasaman Safarkhanlo^1,3,4, Gabriele Bonanno^2,3,5, Adèle Mackowiak^2,3,6, Berk Açikgöz^1,2,3, Eva Peper^2,3, and Jessica Bastiaansen^2,3

¹Graduate School for Cellular and Biomedical Sciences (GCB), University of Bern, Bern, Switzerland, ²Department of Diagnostic, Interventional and Pediatric Radiology (DIPR), Inselspital, University Hospital Bern, Bern, Switzerland, ³Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland, ⁴Department of Cardiology, Inselspital, University Hospital Bern, Bern, Switzerland, ⁵Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Bern, Switzerland, ⁶Department of Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland

Synopsis

Keywords: Multi-Contrast, Quantitative Imaging, bSSFP, brain, T1, T2, Relaxometry, field inhomogeneity, proton density

Motivation: Addressing the need for simplified, time-efficient, and unbiased quantitative imaging in human brain.

Goal(s): Evaluating novel analytical method, ORACLE, to simultaneously quantify T1, T2, proton density (PD), and magnetic field inhomogeneity (B0) in human brain based on balanced steady-state free precession (bSSFP) profiles.

Approach: Acquiring bSSFP data for simultaneous multi-parameter quantification and reference multi-echo spin-echo, MP2RAGE and dual-echo gradient-echo data in 4 human subjects.

Results: Quantifications using bSSFP profiles and ORACLE was consistent with reference methods, although magnetization transfer effects led to a 15% consistent underestimation of T1. Proposed method has faster acquisition and parametric estimation comparing to other methods combined.

Impact: This novel analytical time-efficient method extracts a wide range of quantitative parameters from bSSFP profiles, which can be a valuable alternative to existing reference methods, multi-echo spin-echo, MP2RAGE and dual-echo gradient-echo, that quantify one parameter at a time.

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