Keywords: Relaxometry, Spectroscopy, Downfield
Motivation: NAD+ is a key metabolite in aging and disease, but its absolute in vivo tissue quantification requires correction for T1 and T2 relaxation effects.
Goal(s): Our goal was to determine T1 and T2 of NAD+ in human brain in vivo at 7T.
Approach: We utilized spectrally-selective downfield spectroscopy with slice localization.
Results: We measured an average T1 of 164.6±28.1ms and an average T2 of 33.5±10.3ms across three NAD+ downfield resonances.
Impact: Our measurements of NAD+ T1 and T2 in human brain can be used as correction factors to quantify absolute concentration of NAD+, a potential biomarker to study metabolic derangements in many diseases.
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