Keywords: Blood Vessels, Animals, The glymphatic system
Motivation: The pathogenesis of hypertensive cerebral edema remains elusive
Goal(s): To visualize and evaluate the transport function of the glymphatic system in the spontaneously hypertensive rats (SHR).
Approach: We used the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and immunofluorescence analysis
Results: And we found that there was a significant change in the transport function of the glymphatic system and a decrease in the expression of aquaporin-4 (AQP4) around blood vessels.
Impact: The combination of DCE-MRI and immunofluorescenc analysis can facilitate further exploration of mechanisms underlying brain edema in the spontaneously hypertensive animal models, thus aiding in the study of the glymphatic system.
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