Keywords: Blood Vessels, fMRI (resting state), cerebrovascular reactivity
Motivation: Mapping of cerebrovascular reactivity (CVR) using resting-state BOLD fMRI (RS-fMRI) was raised in 2017 and 2021 with verification using the moyamoya disease (MD). But pathological hemodynamics of MD was missing by RS-fMRI.
Goal(s): Arterial stealing phenomenon can be demonstrated by carbogen-based fMRI (CO2-CVR), but not by RS-fMRI.
Approach: Both RS-CVR and CO2-CVR using a 3T MR and an automatic delivery system of carbogens were acquired for eleven subjects and ten patients with MD. Bland-Altman plots was applied for both RS-CVR and CO2-CVR.
Results: By using CO2-CVR, unique negative CVR of MD verified the arterial stealing phenomenon which was missed by RS-CVR.
Impact: Arterial stealing phenomenon of moyamoya disease/syndrome can be demonstrated as negative cerebrovascular reactivity by carbogen-based fMRI (CO2-CVR), but not by resting-state fMRI (RS-CVR).
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