Keywords: Blood Vessels, Neurofluids, respiratory effects, CBF, cerebral blood flow, phase contrast, real time phase contrast
Motivation: The hydrodynamic characteristics of arterial venous cerebral blood flow (AVCBF) in different breathing patterns remain insufficiently understood.
Goal(s): Quantifying the effects of free and deep breathing on multiple parameters of CBF using real-time phase contrast MRI.
Approach: We applied RT-PC on 14 healthy volunteers to continuously quantify AVCBF dynamics in the main cerebral vessels during free and deep breathing. A time-domain analysis investigated the influence of breathing change on the AVCBF parameters: mean flow, stroke volume, cardiac period.
Results: Deep-breathing decreased global AVCBF dynamics. Mean flows, stroke volumes and cardiac periods decreased but their percentage change between inspiratory and expiratory periods increased.
Impact: This study quantified the effects of free- and deep-breathing on cerebral blood flow dynamics. It should contribute to a better understanding of cerebral hemodynamics and its relation with breathing, providing a valuable reference for clinical applications and physiological studies.
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