Abstract #2206

Amygdala Subregion Atrophy: Early Indicator of Cognitive Impairment in Cerebral Small Vessel Disease

Zhenyu Cheng¹, Meng Li², Jing Li³, Yiwen Chen⁴, Pengcheng Liang⁴, Na Wang⁴, Xinyue Zhang⁴, Changhu Liang⁴, Xianglin Li¹, and Lingfei Guo⁴

¹School of Medical Imaging, Binzhou Medical University, Yantai, Shandong, China., YAN TAI, China, ²Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany, Jena, Germany, ³Department of Radiology, Beijing Tsinghua Changgung Hospital,Beijing, China., Bei jing, China, ⁴Key Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China, Ji nan, China

Synopsis

Keywords: Blood Vessels, Neurodegeneration, Cerebral Small Vessel Disease

Motivation: The motivation behind this study was to delve deeper into the amygdala subregion changes in Cerebral Small Vessel Disease (CSVD) and how these changes correlate with cognitive impairment.

Goal(s): The primary goal was to determine whether specific amygdala subregions could serve as early indicator for cognitive impairment in CSVD, thereby aiding in early diagnosis and intervention.

Approach: Combined 3T MRI neuroimaging with cognitive assessments and focused statistical evaluation of amygdala subregions

Results: Our study revealed significant volume reductions in specific amygdala subregions among CSVD group, with pronounced atrophy observed in the left cortical nucleus.

Impact: This research introduces a novel indicator that utilizes neuroimaging techniques for the early prediction of CSVD progression and associated cognitive impairment, which could significantly enhance the precision of diagnostics and inform effective management strategies for CSVD.

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