Abstract #2210

Brain Iron Deposition in the Posterior Part of the Right Hippocampus Associated with Cognitive Functions in Cerebral Small Vessel Disease

Yiwen Chen^1,2, Meng Li^3,4, Jing Li⁵, Zhenyu Cheng⁶, Pengcheng Liang¹, Na Wang¹, Xinyue Zhang¹, Yuanyuan Wang⁶, Yian Gao¹, Chaofan Sui¹, Changhu Liang¹, and Lingfei Guo¹

¹Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Jinan, Shandong, China, China, ²Shandong First Medical University, Jinan, Shandong, China., Jinan, Shandong, China., China, ³Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany., Jena, Germany., Germany, ⁴Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C), Jena-Magdeburg-Halle, Germany., Jena, Germany., Germany, ⁵Department of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, China., Beijing, China., China, ⁶School of Medical Imaging, Binzhou Medical University, Yantai, Shandong, China., Yantai, Shandong, China., China

Synopsis

Keywords: Blood Vessels, Quantitative Susceptibility mapping, cerebral small vessel disease, hippocampus, iron deposition, cognition.

Motivation: The deposition of excess iron in subcortical nuclei may be linked to the burden of cerebral small vessel disease (CSVD) and could contribute to decreased cognitive performance.

Goal(s): To investigate the relationship between iron deposition in subcortical nuclei and CSVD severity, as well as cognitive impairment.

Approach: Brain iron deposition was assessed by quantitative susceptibility mapping (QSM).

Results: Susceptibility in the posterior part of the right hippocampus (pHIP-R) was negatively correlated with cognitive performance and positively correlated with CSVD severity.

Impact: Iron deposition in pHIP-R could be an early biomarker of CSVD-related cognitive impairment in future research, providing new evidence for investigating the mechanism of cognitive impairment in CSVD.

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