Abstract #2211

Signal changes of amide proton transfer weighted imaging in patients with moyamoya disease: a prospectively longitudinal study

Hongxia Li¹, Chao Xia^1,2, Zhiqin Liu^1,2, Jiaxin Zeng^1,2, Xia Wei^1,2, Ziyu Li^1,2, Xing Li^1,2, Wei Yu^1,2, Yuan Sun^1,2, Yi Liu³, Kai Ai⁴, Na Hu^1,2, and Su Lui^1,2

¹Department of Radiology, West China Hospital, Sichuan University, Chengdu, China, ²Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, China, ³Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China, ⁴Philips Healthcare, Xi'an, China

Synopsis

Keywords: Blood Vessels, CEST & MT

Motivation: Identifying the dynamic changes of the brain microenvironment in patients with moyamoya disease (MMD) would improve disease management and treatment.

Goal(s): To explore the alteration of amide proton transfer weighted (APTw) signal in patients with MMD during the follow-up.

Approach: MMD patients who had not received revascularization were prospectively included. All patients underwent cranial computed tomography perfusion (CTP) and APTw imaging at baseline and at follow-up.

Results: APTw signal in bilateral internal carotid arteries blood supply area significantly increased in MMD patients without surgery during follow-up, and the change of APTw signal was more sensitive than that of CTP.

Impact: APTw imaging could reflect dynamic alterations of the brain microenvironment of patients with MMD over time, and the changes of APTw signal were more sensitive than CTP, which is helpful to improve clinical management.

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