Abstract #2215

Associations between small vessel function and progressive white matter injury in CADASIL using advanced 7T MRI

Stanley Pham¹, Hilde van den Brink², Naomi Vlegels³, Anna Kopczak³, Benno Gesierich^3,4, Alberto de Luca¹, Nikki Dieleman⁵, Jaco Zwanenburg¹, Marco Duering^3,4, Geert Jan Biessels⁵, and Jeroen Siero¹

¹Center for Image Sciences, University Medical Center Utrecht, Utrecht, Netherlands, ²Harvard Medical School, Massachusetts General Hospital, Boston, MA, United States, ³Institute for Stroke and Dementia Research (ISD), Ludwig Maximilian University of Munich, Munich, Germany, ⁴Medical Image Analysis Center (MIAC), University of Basel, Basel, Switzerland, ⁵Neurology, University Medical Center Utrecht, Utrecht, Netherlands

Synopsis

Keywords: Blood Vessels, White Matter, Small vessel disease, white matter hyperintensities, diffusion MRI, pulsatility, vascular reactivity, progressive white matter injury, CADASIL

Motivation: Impaired blood flow velocity and pulsatility on 7T MRI are associated with white matter injury in cerebral small vessel disease (cSVD) cross-sectionally, but it is unclear whether it relates to injury progression.

Goal(s): To assess if small vessel dysfunction is associated with markers of progressive white matter injury in monogenic cSVD.

Approach: Small vessel function was measured on 7T MRI in monogenic cSVD. White matter injury (white matter hyperintensities, peak-skeletonized mean diffusivity) was measured with 3T MRI on baseline and two-year follow-up.

Results: There were no associations between small vessel dysfunction and white matter injury progression in monogenic cSVD.

Impact: Whole-brain white matter injury progression cannot be explained by small vessel function. Local white matter injury progression might be linked with small vessel function and should be assessed in the future with voxelwise studies.

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