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Abstract #2243

MR Contrast-Invariant Deep Learning Method for Synthetic CT Generation

Sandeep Kaushik1,2, Cristina Cozzini1, Jonathan J Wyatt3, Hazel McCallum3, Ross Maxwell4, Bjoern Menze2, and Florian Wiesinger1
1GE HealthCare, Munich, Germany, 2University of Zurich, Zurich, Switzerland, 3Newcastle University and Northern Centre for Cancer Care, Newcastle upon Tyne, United Kingdom, 4Newcastle University, Newcastle upon Tyne, United Kingdom

Synopsis

Keywords: Analysis/Processing, Radiotherapy, synthetic CT, PET/MR, image synthesis

Motivation: Deep learning models are sensitive to image contrast variations. We explore the feasibility of training a single model to process multiple MR contrasts.

Goal(s): To generate synthetic CT images from different MR image contrasts using a image contrast agnostic model.

Approach: A multi-task deep convolutional neural network has been trained using a variety of MR image contrasts.

Results: We demonstrate generation of synthetic CT images from multiple MR images with superior qualitative accuracy and encouraging quantitative accuracy.

Impact: The ability to generate synthetic CT from a variety of MR contrasts brings flexibility of choice of MR sequence in MR guided radiation therapy clinical setup. It improves the model robustness to scan parameter variations leading to a consistent outcome.

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Keywords