Abstract #2277

Multi-vendor Multi-site accelerated high-resolution T1ρ mapping with retrospective and prospective compressed sensing reconstruction

Zhiyuan Zhang^1,2,3, Jeehun Kim^1,2,4, Ruiying Liu⁵, Richard Latery^1,2, Carl Scherman Winalski^1,2,6, Mingrui Yang^1,2, Jing Liu⁷, Qi Peng⁸, Peter Hardy⁹, Thomas Link⁷, Leslie Ying^5,10, and Xiaojuan Li^1,2,6

¹Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, OH, United States, ²Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States, ³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁴Department Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, United States, ⁵Department of Electrical Engineering, University at Buffalo, Buffalo, NY, United States, ⁶Department of Diagnostic Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁷Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ⁸Department of Radiology, Albert Einstein College of Medicine, Bronx, NY, United States, ⁹Department of Radiology, University of Kentucky, Lexington, KY, United States, ¹⁰Department of Biomedical Engineering, University at Buffalo, Buffalo, OH, United States

Synopsis

Keywords: Cartilage, MSK

Motivation: High-resolution T1ρ mapping is desired to improve the early diagnosis of diseases such as osteoarthritis; however, it suffers from long acquisition times.

Goal(s): To accelerate high-resolution T1ρ mapping using compressed-sensing reconstruction in a multi-site multi-vendor setting.

Approach: We standardized the T1ρ imaging protocol between three sites using three MR platforms (GE/Philips/Siemens). Accelerated high-resolution T1ρ mapping with accelerator factors (AF) ranging 8-12 were performed using both retrospective and prospective downsamplings with compressed-sensing reconstruction.

Results: The coefficients-of-variation between reference and accelerated maps were <5% for all sites. Reliable high-resolution T1ρ mapping of the whole knee can be acquired within 7 mins.

Impact: Standardization of the acquisition and reconstruction of accelerated high-resolution T1ρ mapping across sites and MR platforms will greatly facilitate its future use in clinical trials and clinical practice, significantly improving diagnosis and evaluation of responses to interventions/treatments for OA.

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