Keywords: Bone, fMRI
Motivation: Evaluation of sacroiliac subarticular bone marrow edema for active inflammation of ankylosing spondylitis（AS）before and after biologic treatment.
Goal(s): MRI T2 mapping, DWI and SPARCC scores were used to compare the changes of BME in patients with AS before and after biologic treatment.
Approach: DWI, SPARCC scores and T2mapping were compared to evaluate the changes of bone marrow edema in patients with sacroiliac arthritis alone or in combination.
Results: The integrated diagnostic efficacy of DWI and T2 mapping demonstrates an optimal performance.
Impact: The combined application of magnetic resonance diffusion-weighted imaging (DWI), T2 mapping, and STIR-T2WI SPARCC scores provides an effective quantitative method for the clinical evaluation of the therapeutic efficacy of biologics in AS.
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