Keywords: Stroke, Quantitative Imaging, microstructure\stroke
Motivation: Plaque inflammation is the main cause of plaque instability; thus, a convenient and noninvasive method of evaluating intracranial plaque inflammation is needed.
Goal(s): Noninvasive CDT DCE-MRI enables evaluating the inflammation of MCA culprit plaques in patients with IS.
Approach: We compared the CDT DCE-MRI parameters of MCA culprit plaques between patients with acute and non-acute ischemic stroke (IS) and assessed the correlations between these parameters and stroke time.
Results: Ktrans of the CDT DCE-MRI was higher in patients with acute IS than in patients with non-acute IS. Ktrans was significantly negatively correlated with stroke time.
Impact: Ktrans allows non-invasively distinguishing responses to MCA plaque inflammation between patients with acute and non-acute IS. CDT DCE-MRI may be a promising noninvasive tool for accurately assessing large intracranial arterial plaque inflammation.
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