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Abstract #2318

Reproducibility of Whole-Brain Cerebral Blood Flow measurements using phase contrast and arterial spin labeling MRI

Ates Fettahoglu1, Mehdi Khalighi1, Elizabeth Tong1, Michael Moseley1, Greg Zaharchuk1, and Moss Y Zhao1,2
1Department of Radiology, Stanford University, Stanford, CA, United States, 2Department of Neurosurgery, Stanford University, Stanford, CA, United States

Synopsis

Keywords: Stroke, Neurofluids, Perfusion, Reproducibility

Motivation: We investigated the reproducibility of cerebral blood flow (CBF) measurement techniques with phase contrast (PC) and arterial spin labeling (ASL) MRI given their importance in diagnosing cerebrovascular diseases.

Goal(s): Demonstrate the reproducibility of phase contrast and arterial spin labeling MRI techniques for measuring CBF.

Approach: We used comparative analysis of CBF measurements using phase contrast and arterial spin labeling pre- and post- diamox vasodilation test, measured twice by a week apart.

Results: Strong interclass correlation across modalities and sessions, indicating strong reproducibility for both techniques.

Impact: We conclude that PC- and ASL- MRI measurements are in good agreement and have strong inter-session reproducibility in measuring CBF before and after vasodilation.

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Keywords