Keywords: Stroke, Neuroscience, cerebral blood flow; gray matter volume; gray matter asymmetry; high-risk non-disabling ischemic cerebrovascular events;
Motivation: Patients with high-risk non-disabling ischemic cerebrovascular events (HR-NICE) are recommended as the key population for stroke prevention. However, the functional impairment and underlying neural mechanisms are rarely investigated in this cohort.
Goal(s): We attempt to confirm the neural and cognitive impairment and explain the mechanism of cognitive impairment in aspects of both hypoperfusion and cortical abnormality in HR-NICE patients.
Approach: Cerebral blood flow, grey matter volume and asymmetry were calculated based on MR perfusion and anatomical data.
Results: Hypoperfusion and cortical abnormality are significant in HR-NICE patients, these neural impairments are robustly correlated with cognitive decline.
Impact: Our study confirmed the existence of early neural damage in HR-NICE patients, which is reflected in multiple aspects of hypoperfusion, grey matter atrophy and decreased asymmetry. These abnormalities collectively contribute to cognitive decline, especially in patients with left involvement.
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