Abstract #2339

Two novel applications of 3D amplified MRI (aMRI)

Haribalan Kumar¹, Paul Condron^2,3, Daniel Cornfeld², Itamar Terem⁴, Eryn Kwon^2,3,5, Jesse Gale^2,6, Graham Wilson^2,7, Helen Helen Danesh-Myer^8,9, and Samantha Holdsworth^2,3

¹GE Healthcare, Gisborne, New Zealand, ²Mātai Medical Research Institute, Gisborne, New Zealand, ³Faculty of Medical & Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand, ⁴Stanford University, Stanford, CA, United States, ⁵Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand, ⁶Department of Surgery & Anaesthesia, University of Otago, Wellington, New Zealand, ⁷Department of Medicine, University of Otago, Dunedin, New Zealand, ⁸Department of Ophthalmology, University of Auckland, Auckland, New Zealand, ⁹Vision Research Foundation, Auckland, New Zealand

Synopsis

Keywords: Spinal Cord, Spinal Cord, Optical nerve

Motivation: We intend to employ advanced imaging methods to explain pathologic clinical scenarios involving the spine and optical nerve sheath. Motion in these applications is driven by cardiac pulsatility, and the pulsatile motion occurs across CSF-tissue boundary.

Goal(s): In this work, we tested if cardiac-gated cine MR imaging combined with video amplification can visualize sub-voxel motion.

Approach: Pulsatile motion profiles were extracted and quantitatively compared.

Results: Pulsatile motion in healthy and pathological use cases are compared.

Impact: Amplified MRI (aMRI) is a visualization method that shows pulsatile dynamics and is used to study brain pulsation. We have shown additional use-cases in spinal cord motion and optical nerve sheath dynamics.

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