Abstract #2344

Distinct progression patterns of white matter microstructure in Parkinson’s disease associated with REM sleep behavior disorder

Sijia Tan¹, Jiaqi Wen¹, Chenqing Wu¹, Xiaojie Duanmu¹, Cheng Zhou¹, Qianshi Zheng¹, Jianmei Qin¹, Weijin Yuan¹, Haoting Wu¹, Tao Guo¹, Jingwen Chen¹, Jingjing Wu¹, Yong Zhang², Minming Zhang¹, Xiaojun Guan¹, and Xiaojun Xu¹

¹zhejiang university school of medicine, Hangzhou, China, ²GE Healthcare, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Neurodegeneration, Rapid eye movement sleep behavior disorder

Motivation: Rapid eye movement sleep behavior disorder (RBD) significantly impacts clinical outcomes in Parkinson's disease (PD).

Goal(s): Our goal was to investigates the neurophysiological mechanisms related to motor and cognitive decline longitudinally in PD with RBD (PD-RBD).

Approach: We used diffusion tensor imaging and clinical assessments on 83 PD patients over 2 years, two groups were formed: PD-RBD and PD without RBD (PD-nonRBD).

Results: PD-RBD experienced widespread decline in white matter microstructure which are associated with motor symptoms aggravation, while PD-nonRBD patients showed limited changes.

Impact: The presence of RBD suggests more extensive white matter degeneration in PD, particularly affecting motor symptoms.

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