Keywords: Stroke, Stroke, Resting-state fMRI, ischemic stroke, regional homogeneity, amplitude of low-frequency, penumbra, perfusion
Motivation: Functional changes in ischemic penumbra after cerebral infarction may indicate different degrees of hypoperfusion and different prognosis.
Goal(s): To explore the functional characteristics of infarction and its penumbra region using rs-fMRI.
Approach: The functional differences between infarct, penumbra and contralateral normal tissue were evaluated by Paired sample t test and Wilcoxon paired sign-rank test. Spearman correlation analysis was used to evaluate the correlation between the degree of hypoperfusion of the penumbra and the functional impairment.
Results: Substantial differences in functional characteristics were observed between infarction and normal tissue. The degree of ischemic penumbra was considerably correlated with its functional characteristics.
Impact: The elucidation of penumbral functional characteristics may influence its reversibility potential. Such knowledge can be pivotal in guiding clinical decision-making related to thrombolytic and neuroprotective treatments, optimizing patient outcomes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords