Abstract #2359

Reduced cerebral oxygen extraction and metabolic rate in newborns with hypoxic ischemic encephalopathy

Dengrong Jiang¹, W. Christopher Golden², Zhiyi Hu³, Sandrine Yazbek⁴, Aylin Tekes¹, Wen Shi³, Yifan Gou³, Jennifer Shepard², Fulden Aycan⁵, Charlamaine Parkinson², Hanzhang Lu¹, Frances J. Northington², Dina El-Metwally⁵, and Peiying Liu⁴

¹Department of Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁴Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States, ⁵Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Neonatal, Oxygenation

Motivation: Over 40% of neonates with moderate or severe hypoxic-ischemic-encephalopathy (HIE) still suffer from death, disability or neurodevelopmental delay after standard hypothermia treatment. Assessment of the brain’s oxygen metabolism may provide useful biomarkers to identify the risk of permanent neurologic injury and determine the necessity of adjuvant treatments.

Goal(s): To evaluate cerebral oxygen-extraction-fraction (OEF) and cerebral-metabolic-rate-of-oxygen (CMRO2) in neonates with HIE in comparison with healthy newborns.

Approach: We measured OEF and CMRO2 in 42 neonates with HIE and 52 healthy newborns.

Results: Neonates with HIE exhibited diminished OEF and CMRO2. Furthermore, a lower OEF predicted a longer stay in the neonatal ICU.

Impact: The brain’s physiological parameters such as oxygen-extraction-fraction can provide additional information (beyond standard clinical indices) for cerebral injury evaluation and treatment planning for hypoxic-ischemic-encephalopathy.

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