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Abstract #2365

T1-Weighted MP2RAGE Optimisation for Neonates at 7T

Ayse Sila Dokumaci1,2, Alena Uus1,3, Philippa Bridgen2,4, Beya Bonse4, Ines Tomazinho4, Raphael Tomi-Tricot1,2,3,5, Pierluigi Di Cio4, Aiman Mahmoud1, Joseph V. Hajnal1,2,3, Maria Deprez1,3, Tomoki Arichi3,4,6, David W. Carmichael1,2, and Shaihan J. Malik1,2,3
1Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 2London Collaborative Ultra high field System (LoCUS), London, United Kingdom, 3Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, 4Guy's and St Thomas’ NHS Foundation Trust, London, United Kingdom, 5MR Research Collaborations, Siemens Healthcare Limited, London, United Kingdom, 6MRC Centre for Neurodevelopmental Disorders, King’s College London, London, United Kingdom

Synopsis

Keywords: Neonatal, Neonatal

Motivation: There is currently no high contrast structural T1-weighted protocol available for neonatal imaging at ultrahigh field (7T), as the longer T1 relaxation times make existing protocols optimized for older subjects unsuitable.

Goal(s): To produce submillimeter T1-weighted images for neonates at 7T in a clinically feasible scan time.

Approach: We optimised a T1-weighted MP2RAGE protocol using the genetic algorithm for constrained optimisation while accounting for transmit field inhomogeneities.

Results: 3D whole-brain images with 0.65-0.8mm isotropic resolution were acquired in under 6-7 minutes from 3 infants. Quantitative T1 maps were produced using an in-house fitting algorithm.

Impact: We describe the first neonatal optimised MP2RAGE protocol for acquiring high-contrast submillimeter-resolution images with full-brain coverage that are relatively insensitive to transmit field inhomogeneities.

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Abstract

Keywords