Keywords: Neuro, Brain, Cerebral palsy, Periventricular white matter injury, MRI, Diagnose, MultiReader MultiCase
Motivation: Early diagnosis of cerebral palsy in infants with periventricular white matter injury is crucial for rehabilitation.
Goal(s): To develop and externally validate a MRI-based model to predict CP in infants with PWMI aged 6 to 24 months, and evaluate the diagnostic performance of the model using the MRMC analysis.
Approach: In this study, A MRI-based multivariable logistic regression model was develop at one center , and was validated at the three centers, and to evaluate the diagnostic performance of the model using the MRMC analysis.
Results: The model showed both excellent predictive performance in the multicenter cohorts and high diagnostic performance in MRMC analysis.
Impact: Our model is a reliable and reproducible tool for diagnosis of CP in infants with PWMI aged 6 to 24 months.
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