Keywords: Neuro, MR-Guided Interventions
Motivation: Transcranial magnetic stimulation (TMS)-assisted rehabilitation therapy has demonstrated the potential to enhance prognoses in spastic cerebral palsy (SCP). However, there are still great differences in the efficacy among individuals.
Goal(s): We employed personalized MRI-guided TMS to precisely target symptomatic neural circuits in children with SCP.
Approach: We used DSI Studio software to track symptom-related fibre bundles within the cortex for targeting and analysed MRI structural and functional differences before and after treatment.
Results: Our findings revealed post-treatment improvements in the quantity, maximum length, and mean length of fiber bundles. Additionally, enhanced neural activity and improved consistency of neural signals were observed after treatment.
Impact: Individualized MRI-guided TMS interventions have shown promise in ameliorating neurological symptoms in individuals with SCP.
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