Keywords: Normal Development, Normal development, Infants, Myelination, Preterm, ASD
Motivation: Myelination in the human brain extends from late pregnancy to the end of adolescence. Yet, its developmental pattern during this period is not fully understand.
Goal(s): We use the BCP dataset to investigate early brain myelination between 0-6 years old.
Approach: We utilized T1-/T2-weighted intensity, a surrogate marker for myelin.
Results: We identified five spatial patterns with distinct developmental trajectories and investigated the biological implications of myelination on developmental diseases, finding that the myelin content of corpus callosum had a significant fully mediated effect on ASD-related indicators. Furthermore, we found an alternation of myelination development affected by preterm birth in a separate cohort.
Impact: We investigated myelination patterns in infants and toddlers by T1w/T2w based on the BCP dataset and identified five distinct regional developmental trajectories. Using a mediation analysis, we found an intrinsic association between myelination and ASD-related restricted repetitive behaviors.
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