Abstract #2391

Altered association of cortical thickness with cognitive abilities in very preterm children at 6 years of age

Hyejin Jeong¹, Uk-Su Choi², and So Yeon Shim³

¹Neuroscience Convergence Center, Institute of Green Manufacturing Technology, Korea University, Seoul, Korea, Republic of, ²Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea, Republic of, ³Division of Neonatology, Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea, Republic of

Synopsis

Keywords: Normal Development, Pediatric

Motivation: Very preterm children have a risk of impaired cognitive function mediated by several risk factors. The association between structural alteration and high-order cognitive function remains unclear.

Goal(s): Very preterm children at 6 years old showed significant differences in cortical thickness associated with cognitive abilities compared with term infants.

Approach: Cortical thickness was assessed in 41 very preterm and 24 full-term children at 6 years of age. The cortical thickness analysis of structural T1-weighted images was performed using Advanced Normalization Tools.

Results: Perceptual reasoning indices, high-order cognitive function, were found to be broadly correlated with cortical thickness in both very preterm and term children

Impact: This study explores the between brain structure changes and cognitive abilities in very preterm and full-term children, providing insights for neurodevelopmental diagnosis.

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